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Guadalupe is a city and it surrounding municipality located in the state of Nuevo Leon, in northern Mexico. It is part of the Greater Monterrey Metropolitan area.
The city was founded on January 4, 1716, but the land was inhabited long before that. When Monterrey was founded in 1596, the land, which was populated by various indigenous tribes, was ceded to Diego de Montemayor, the founder of Monterrey, but he did not make use of the land. In 1627, the land was turned into large plantations, where sugar cane and corn was raised. The owner of the land during around the time of the turn of the 18th century was named Capitan Nicolas Ochoa de Elejalde, but the land was taken from him by the Spanish government and converted into a mission in February, 1715. In 1756, the city was renamed the "Pueblo de la Nueva Tlaxcala de Nuestra Senora de Guadalupe de Horcasitas". On March 5, 1825, the city was declared a municipality of Nuevo Leon and categorized as a villa, even though for many years it continued to be called the "Villa de Guadalupe".