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Tapachula is a municipio (municipality) and city with a hot, humid climate in the Mexican state of Chiapas. It is located in southern part of the state on the Soconusco coastal plain, near the border with Guatemala, at 14.91° N 92.27° W. In the 2005 census the population of the municipality was 282,420 people, whereas the city of Tapachula had a population of 189,991 (more than two-thirds of the municipality's total). The city and the municipality both rank second in the state in population, behind Tuxtla Gutierrez.

The city has one of the highest GDP per capita in Mexico, and it is known sometimes as "Perla del Soconusco" ("Pearl of Soconusco").